Jin Wang Ph.D

Professor, PI, Shanghai Public Health Clinical Center, Fudan University. Dr. Wang has been working in the fields of cancer and infectious diseases. For a major focus of his research is to develop novel early detection biomarkers of human cancers utilizing various state of the art genomic technologies, he has been able to identify several interesting candidate biomarkers of human pancreatic cancers and liver cancer, which published in JCP in 2016, 2015, Cancer Lett in 2015, Clin Chem in 2015, BMC Cancer in 2014, and Cancer Prev Res in 2009; for development of nature compounds treatment with cancer, his work is centered around the study of the molecular mechanisms of anti-cancer drugs and has significant application in cancer treatment, which published in J Cancer in 2015, Sci Rep in 2014, JBC in 2013, Cancer Cell in 2012, and Liver International in 2009. Dr. Wang has authored/co-authored 2 patents (U.S. WO Patent WO/2012/030,956; P.R.China Patent NO: 99113481.8) and over 30 SCI publications with a citation rate of over 800. He has received the prestigious Anne Eastland Spears Fellowship award in Gastrointestinal Cancer Research from the University of Texas, M.D. Anderson Cancer Center in USA and three independent fellowships from reputed institutions. His laboratory conducts basic and translational research in the following areas: 1) Development of novel early detection biomarkers of human Gastrointestinal (GI) cancers; 2) Pharmacologic ascorbic acid, all-trans retinoid acid and miRNAs for treatment of cancer and infectious diseases. 

EDUCATION:
2008-2010: Postdoctoral Fellow, Dept of Molecular Pathology, The University of Texas, M.D. Anderson Cancer Center, Houston, TX 77054, USA;
2004-2008: Postdoctoral Fellow, Molecular and Clinical Nutrition Section, National Institute of Diabetes & Digestive & Kidney Diseases, National Institutes of Health, (NIH/NIDDK), Bethesda, MD 20892, USA;
2000-2003: Ph.D. in Biology, City University of Hong Kong, Hong Kong, China;
1994-1997: MS in Immunology, The Shanghai Second Medical University, Shanghai, China.
PROFESSIONAL APPOINTMENTS:
2015-Present: PI, Professor, Scientific Research Center, Shanghai Public Health Clinical Center, Fudan University, Shanghai, China;
2010-2015: Research Scientist, Dept of Translational Molecular Pathology, The University of Texas, M.D. Anderson Cancer Center, Houston, TX 77030, USA;
1998-2000: Instructor, State Key Laboratory of Genetic Engineering, FudanUniversity, Shanghai, China.
AFFILIATIONS AND HORNORS:
American Association of Cancer Research;
The Anne Eastland Spears Fellowship in GI Cancer Research, 2010;
M.D. AndersonCancerCenter Fellowship, 2008-2010;
IRTA Fellowship, National Institutes of Health, 2004-2008;
Graduate Studentship, CityUniversity of Hong Kong Fellowship, 2000-2003.

PUBLICATIONS: (2009~):
1. Zhang X, Tong P, Chen J, Pei Z, Zhang X, Chen W, Xu J, Wang J*. Identification of Novel Biomarkers for Pancreatic Cancer Using Integrated Transcriptomics with Functional Pathways Analysis. J Cell Physiol 2016 Feb 22. doi: 10.1002/jcp.25353.
2. Huang J, Liu SM*, Ma H, Yang Y, Zhang X, Sun H, Zhang X, Xu J, Wang J*. Systematic Review and Meta-analysis: Circulating miRNAs for Diagnosis of Hepatocellular Carcinoma. J Cell Physiol 2016; 231(2): 328-335.
3. Li S, Wang J, Yang Y, Liu ZJ, Cheng L, Liu HY, Ma P, Luo W, Liu SM*. Polymorphisms in FADS1 and FADS2 alter plasma fatty acids and desaturase levels in type 2 diabetic patients with coronary artery disease. J Transl Med 2016; Mar 22;14(1):79. doi: 10.1186/s12967-016-0834-8.
4. Wang J, Chen J, Sen S. microRNA as Biomarkers and Diagnostics. J Cell Physiol 2016 ; 231(1): 25-30.
5. Ma H, Mallampati S, An G, Wang J. Targeted Therapy in Hematological Malignancies: From Basic Research to Clinical Practice. Biomed Res Int 2015; 2015: 157570.
6. Wang J*, Yan B, Liu S-M, Sun H, Pan Y, Guan D, Zhang X, Xu J, Ma H*. Transcriptomic and Functional Pathway Analysis of Human Cervical Carcinoma Cancer Cells Response to Microtubule Inhibitor. J Cancer. 2015, 6(10): 930-937.
7. Wang J, Yin H, Panandikar A, Gandhi V, Sen S. Elevated cyclin A associated kinase activity promotes sensitivity of metastatic human cancer cells to DNA antimetabolite drug. Int J Oncol 2015; 47(2):782-790.
8. Fujii S, Srivastava V, Hegde A, Kondo Y, Shen L, Hoshino K, Gonzalez Y, Wang J, et al. Regulation of AURKC expression by CpG island methylation in human cancer cells. Tumour Biol 2015; 36(10): 8147-8158.
9. Huang JT#, Liu YJ#, Wang J#, Xu ZG, Yang Y, Shen F, Liu XH, Zhou X, Liu SM. Next-Generation Digital PCR Measurement of HBV Copy Number in Formalin-Fixed Paraffin-Embedded Hepatocellular Carcinoma Tissue. Clin Chem 2015; 61(1): 290-296.
10. Wang J, Paris PL, Chen J, Ngo V, Yao H, Frazier ML, Killary AM, Liu CG, Liang H, Mathy C, Bondada S, Kirkwood K, Sen S. Next Generation Sequencing of Pancreatic Cyst Fluid microRNAs from Low Grade- Benign and High Grade- Invasive Lesions. Cancer Lett 2015; 356: 404-409.
11. Sun H, Ma H*, Hong G, Sun H, Wang J*. Survival improvement in patients with pancreatic cancer by decade: A period analysis of the SEER database, 1981-2010. Sci Rep 2014; 4: 6747.
12. Wang J#, Raimondo M#, Guha S#, Chen J, Diao L, Dong X, Wallace MB, Killary AM, Frazier ML, Woodward TA, Wang J, Sen S. Circulating microRNAs in Pancreatic Juice as Candidate Biomarkers of Pancreatic Cancer. J Cancer 2014; 5(8): 696-705.
13. Qi JH#, Wang J#, Chen J, Shen F, Huang JT, Sen S, Zhou X, Liu SM. High-resolution melting analysis reveals genetic polymorphisms in MicroRNAs confer hepatocellular carcinoma risk in Chinese patients. BMC Cancer 2014; 14: 643.
14. Wang J, Zhang KY, Liu SM, Sen S. Tumor-Associated Circulating MicroRNAs as Biomarkers of Cancer. Molecules. 19, 1912-1938. 2014.
15. Liu SM, Chen W, Wang J*. Distinguishing between cancer cell differentiation and resistance induced by all-trans retinoic acid using transcriptional profiles and functional pathway analysis. Sci Rep 2014; 4: 5577.
16. Huang J, Wang J*, Srivastava V, Sen S, Liu S*. MicroRNA Machinery Genes as Novel Biomarkers for Cancer. Front Oncol 2014; 4:113.
17. Liu Q, Chen J, Wang J, Amos C, Killary AM, Sen S, Wei C, Frazier ML. Tumor suppressor gene SEL1L was downregulated by aberrantly upregulated Hsa-mir-155 in human pancreatic ductal adenocarcinoma. Mol Carcinog 2014; 53(9):711-721.
18. Qi J, Wang J*, Katayama H, Sen S, Liu SM*. Circulating microRNAs (cmiRNAs) as novel potential biomarkers for hepatocellular carcinoma. Neoplasma 2013; 60(2): 135-142.
19. Corpe C, Eck P, Wang J, Al-Hasani, H Levine M. Intestinal Dehydroascorbic acid (DHA) transport mediated by the facilitative sugar transporters, GLUT2 and GLUT8. J Biol Chem 2013, 288(13): 9092-9101.
20. Katayama H, Wang J, Treekitkarnmongkol W, Kawai H, Sasai K, Zhang H, Wang H, Adams HP, Jiang S, Chakraborty SN, Suzuki F, Arlinghaus RB, Liu J, Mobley JA, Grizzle WE, Wang H, Sen S. Aurora Kinase-A Inactivates DNA Damage Induced Apoptosis and Spindle Assembly Checkpoint Response Functions of p73. Cancer Cell 2012; 21(2): 196-211.
21. Wang J and Sen S. MicroRNA Functional Network in Pancreatic Cancer: From Biology to Biomarkers of Disease. J Biosci 2011; 36: 481-491.
22. Corpe CP, Tu H, Eck P, Wang J, Faulhaber-Walter R, Schnermann J, Margolis S, Padayatty S, Sun H, Wang Y, Nussbaum RL, Espey MG, Levine M. Vitamin C transporter slc23a1 links renal reabsorption, control of vitamin C concentrations, and perinatal survival. J Clin Invest 2010; 120(4): 1069-1083.
23. Jiang S, Katayama H, Wang J, Radvanyi L, Li SA, Li JJ, Sen S. Estrogen Induced Aurora Kinase-A (AURKA) Gene Expression is Activated by GATA-3 in Estrogen Receptor Positive Breast Cancer Cells. Hormones and Cancer 1(1): 11-20, 2010.
24. Wang J, Chen J, Chang P, Li D, Abbruzzesse JL, Frazier ML, Killary AM, Sen S. MicroRNAs in Plasma of Pancreatic Ductal Adenocarcinoma Patients as Novel Blood Based Biomarkers of Disease. Cancer Prevention Research 2009, 2(9): 807-13.
25. Wang J, Chan JY, Fong CC, Tzang CH, Fung KP, Yang M. Transcriptional analysis of doxorubicin- induced cytotoxicity and resistance in human hepatocellular carcinoma cell lines. Liver Int. 2009, 29: 1338-47.
26. Wang J, Fong CC, Tzang CH, Xiao P, Han R, Yang M. Gene expression analysis of human promyelocytic leukemia HL-60 cell differentiation and cytotoxicity induced by natural and synthetic retinoids. Life Sci 2009, 84: 576-83.

(*Corresponding author; #Co-first author ).

BOOK CHAPTERS:
1. Jin Wang and Subrata Sen. Chapter 4: miRNAs in Solid Tumors, Non-coding RNAs and cancer. Muller Fabbri, Editor. Springer. pp45-65. 2014.
2. Mark Levine, Sebastian Padayatty, Christopher Corpe, Jin Wang, Qi Chen, Liqun Zhang. Chapter R27: Vitamin C. Biochemical and Physiological Aspects of Human Nutrition, M Stipanuk, Editor. Second Edition, W. B. Saunders Publisher. 2005.
3. Yaou Zhang, Jin Wang, Chi-Hung Tzang and Mengsu Yang. Chapter 17: Applications of cDNA microarray technique in cancer research, Chemical Prevention and Therapeutic Treatment of Cancer of the New Millenium , Han R and Sun Y (eds) , pp 259-271, People's Military Medical Press, Beijing, PRC, 2005. [Chinese].

PATENTS:
1. Subrata Sen, Jin Wang. MIRNA DETECTION OF PANCREATIC CANCER. U.S. WO Patent WO/2012/030,956. 2012.
2. Jin Wang, Yu-min Mao, Shi-ping Wang, Lu-wei Zhou, Jim Hang, DNA Chip on ITO-glass supports, P.R.China Patent NO: 99113481.8, 1999.

 
Contact: 
Dr. Jin Wang
Adress: Scientific Research Center, Shanghai Public Health Clinical Center, 2901 Caolang Road, Jinshan, Shanghai 201508, China
Tel: +011-86-21-37990333-7336;(直线:011-86-21-57036495);
Cell: +011-86-18930813976;
Fax: +011-86-21-57036411;
Email: wangjin@shaphc.org; wjincityu@yahoo.com
Website: https://www.researchgate.net/profile/Jin_Wang18